After the cutscene, a GIANT MECHANICAL EYEBALL emerges from the floor. Throughout this battle, the eyeball will sink into the sand then pop up elsewhere scattering poison orbs in all directions. Try to avoid these orbs, especially if you don't have poison resistance yet.
Each time the eyeball appears, move in quickly, plant a remote bomb close to it, get out of the way...
...and then detonate the bomb before the eye disappears again. Each successful strike chips away at its health bar.
When you've damaged the eyeball by about a third, swarms of regular and giant scarabs, including poisonous and flaming varieties, emerge from the vents around the perimeter. You'll need to fight them while continuing to avoid the poison orbs and bomb the eyeball itself. The flamethrower kills scarabs fairly quickly, but it also allows them to get close before you torch them, so you may suffer some poison and/or fire damage in the process. Fortunately some of the bugs leave behind health packs, ammo, and/or gems.
In addition to the scarabs, the watching eyes along the walls will wake up and begin shooting smaller poison orbs, which you'll need to dodge as well.
You can shoot the eyes on the wall, but it's more important to concentrate on the main eye.
If you can lure the scarabs near the giant eyeball, you may be able to use your bombs...
...to damage both the bugs and the boss.
Keep moving, dodging the poison orbs, fighting the bugs, and bombing the eyeball...
...and before long you'll destroy it. When it explodes, so do the smaller eyes mounted on the wall.
The giant eye leaves behind a hail of gems and the SHAPELY LEFT LEG OF OSIRIS.
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